Cbz-Val-Cit-PAB-OH (CAS: 159858-07-8) is a cleavable linker for antibody-drug conjugates (ADCs) and drug development. It contains a dipeptide for enzyme-specific cleavage, and a PAB spacer for drug release.
Key Features:
- Cleavable Linker: Targets cathepsin B for drug release inside cells.
- PAB Spacer: Improves drug release after cleavage.
- Cbz-Protecting Group: Protects the amine group during synthesis and removes easily.
Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies for targeted cancer treatment.
- Bioconjugation: Creates stable, enzyme-responsive drug conjugates.
- Drug Development: Builds enzyme-activated prodrugs and therapeutic agents.
This linker supports precise drug delivery, enhancing therapeutic effectiveness and reducing side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
