Cbz-N-Amido-PEG1-acid
This product is a compact PEG1 linker with a Cbz-protected amide and a terminal carboxylic acid. The short PEG1 spacer provides minimal but effective hydrophilicity and flexibility, while the Cbz group offers stable carbamate protection for orthogonal conjugation strategies.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate protecting group, removable by hydrogenolysis.
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Carboxylic Acid Group: Couples efficiently with amines to form stable amide bonds.
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PEG1 Spacer: Compact design reduces steric hindrance while maintaining solubility.
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High Purity: Ensures reproducibility in sensitive conjugation and synthesis workflows.
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Orthogonal Reactivity: Supports stepwise and selective synthetic strategies.
Applications:
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Bioconjugation: Enables precise biomolecule attachment with minimal PEG spacing.
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Drug Delivery: Improves solubility and stability in therapeutic conjugates.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymers.
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Synthetic Chemistry: Serves as a protected intermediate in orthogonal synthesis.
Storage and Handling:
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Storage: Store at –20 °C, protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid stability.
This product combines compact PEG spacing with dual reactivity, making it an especially efficient reagent for orthogonal conjugation and material modific
ation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
