Carbamic-acid,[2-[2-(2-hydroxyethoxy)ethoxy]ethyl],9H-fluoren-9-ylmethyl-ester-(9CI)

Carbamic-acid,[2-[2-(2-hydroxyethoxy)ethoxy]ethyl],9H-fluoren-9-ylmethyl-ester-(9CI)

Carbamic-acid,[2-[2-(2-hydroxyethoxy)ethoxy]ethyl],9H-fluoren-9-ylmethyl-ester-(9CI) (commonly referred to as Fmoc-PEG3-alcohol) is a high-purity PEG linker featuring an Fmoc-protected carbamate group for orthogonal conjugation and a terminal hydroxyl group for further functionalization. The PEG3 spacer enhances solubility, provides flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The Fmoc group allows controlled deprotection for stepwise linker assembly in applications such as drug discovery, diagnostics, and advanced materials.

Key Features and Benefits

• Fmoc-Protected Amine Precursor: Enables controlled deprotection for orthogonal conjugation.

• Terminal Hydroxyl Group: Allows further derivatization into esters, ethers, or activated intermediates.

• PEG3 Spacer: Improves water solubility, molecular flexibility, and accessibility of functional groups.

• High Purity: >95% purity ensures reproducibility and reliable performance.

Applications

• Stepwise Bioconjugation: Assemble multifunctional linkers in a controlled sequence.

• Peptide and Protein Modification: Introduce PEG spacers to improve solubility and reduce aggregation.

• Nanoparticle Functionalization: Add hydroxyl-terminated linkers to particle surfaces for tailored reactivity.

• Drug Delivery Systems: Build precision linkers for controlled payload attachment and release.

• Diagnostic Probes: Develop PEG-based imaging and sensing tools.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.

Carbamic-acid,[2-[2-(2-hydroxyethoxy)ethoxy]ethyl],9H-fluoren-9-ylmethyl-ester-(9CI) combines an Fmoc-protected carbamate and a hydroxyl group within a PEG3 spacer, offering orthogonal reactivity, excellent solubility, and versatility for building multifunctional bioconjugates.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.