Bromoacetamide-PEG5-propargyl(CAS:1807521-10-3) is widely used for thiol labelling and thiol capping reagent. It undergoes a fast nucleophilic substitution reaction with thiol. the propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The PEG spacer increase the solubility of the resulting complex in aqueous media.
Drug Delivery Systems: Bromoacetamido-PEG5-Propargyl can be employed to conjugate drug molecules to targeting ligands, such as antibodies or peptides, facilitating targeted drug delivery to specific cells or tissues. The PEG linker enhances the pharmacokinetic properties of the conjugate, while the click chemistry reaction enables the attachment of additional functional groups or imaging agents for monitoring.
Antibody-Drug Conjugates (ADCs): The selective reactivity of bromoacetamide with cysteine residues makes Bromoacetamido-PEG5-Propargyl an ideal candidate for constructing ADCs. These conjugates combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs, improving the therapeutic index and reducing side effects.
Bioimaging: The bioorthogonal click chemistry reaction facilitated by the propargyl group enables the attachment of fluorophores, radiolabels, or other imaging agents to biomolecules, creating imaging probes for the visualization and tracking of cellular processes and molecular interactions in real time.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
