DBCO-NH-PEG4-NH-Boc
This product is a high-purity heterobifunctional PEG linker featuring a DBCO group for copper-free click chemistry and a Boc-protected amine for orthogonal conjugation, specifically connected by a PEG4 spacer for solubility and flexibility.
Key Features and Benefits
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DBCO Group – Enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides.
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Boc-Protected Amine – Provides a latent amine handle that can be deprotected under acidic conditions for selective conjugation.
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PEG4 Spacer – Improves solubility, reduces steric hindrance, and enhances molecular accessibility.
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High Purity – Suitable for bioorthogonal chemistry, dual labeling, and advanced drug conjugation strategies.
Applications
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Copper-free click conjugation with azide-modified biomolecules
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Orthogonal dual-labeling strategies via amine deprotection
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Bioconjugation for antibody, peptide, and protein functionalization
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Use in drug delivery, diagnostics, and probe development
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product combines copper-free click reactivity and a Boc-protected amine handle on a PEG4 spacer, specifically providing solubility, flexibility, and precise control for orthogonal conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
