BocNH-PEG3-acid-amine DBCO
This product is a multifunctional PEG linker that combines a dibenzocyclooctyne (DBCO) group, a PEG3 spacer, a Boc-protected amine, and a terminal carboxylic acid. It specifically enables copper-free click chemistry with azides, orthogonal amine conjugation after deprotection, and amide bond formation.
Key Features and Benefits
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DBCO Group: Supports strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG3 Spacer: Improves solubility and reduces steric hindrance.
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Boc-Protected Amine: Provides orthogonal reactivity upon selective deprotection.
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Carboxylic Acid: Couples efficiently with amines for stable amide bonds.
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Multifunctional Design: Combines three orthogonal chemistries in one linker.
Applications
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Bioconjugation: Links azide-, amine-, and carboxyl-containing biomolecules.
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Probe Development: Builds multifunctional probes with dual click and amide handles.
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Drug Delivery: Provides PEGylated scaffolds with multiple reactive sites.
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Material Science: Functionalizes polymers and nanoparticles with versatile chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates copper-free click reactivity, amide coupling, and orthogonal amine chemistry into a PEG3 scaffold, providing an especially versatile tool for multifunctional linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
