Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group.
Boc-Val-Cit-PAB is belongs to the class of peptide derivatives. This compound consists of a tripeptide sequence, Boc-Val-Cit, attached to a para-aminobenzoic acid (PAB) moiety. The Boc group is a protective group for the Valine amino acid, while Cit refers to citrulline, an amino acid with a guanidino group. The PAB group contains an aromatic ring and an amino group, making it an ideal functional group for further conjugation reactions.
Boc-Val-Cit-PAB has been extensively used in the field of pharmaceutical research and development, particularly in the development of antibody-drug conjugates (ADCs). ADCs are a class of targeted therapeutics that combine the specificity of monoclonal antibodies with the cytotoxicity of small-molecule drugs. Boc-Val-Cit-PAB is used as a linker moiety to covalently attach a cytotoxic drug to an antibody. The PAB group allows for the attachment of the drug through an amide bond, while the tripeptide sequence provides stability and hydrophilicity to the conjugate.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
