t-Boc-aminooxy-PEG4-amine
This product is a heterobifunctional PEG linker containing a Boc-protected aminooxy group, a PEG4 spacer, and a primary amine. It specifically enables oxime ligation, orthogonal deprotection, and amide coupling, offering solubility, flexibility, and multifunctionality.
Key Features and Benefits
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Boc-Protected Aminooxy: Allows selective deprotection for oxime ligation with aldehydes and ketones.
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Primary Amine: Couples efficiently with carboxyls, NHS esters, or activated linkers.
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PEG4 Spacer: Provides solubility and medium chain length.
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Dual Reactivity: Combines protected aminooxy chemistry with active amine conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links carbonyl-containing and amine-reactive biomolecules.
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Probe Development: Builds multifunctional probes with orthogonal handles.
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Drug Delivery: Provides PEG scaffolds with solubility and orthogonal reactivity.
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Organic Synthesis: Serves as a versatile intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Boc removal.
This product integrates protected aminooxy chemistry with amine reactivity in a PEG4 scaffold, specifically offering solubility, flexibility, and multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
