t-Boc-aminooxy-PEG4-amine CAS:1235514-18-7 is a cutting-edge, bifunctional reagent that has emerged as a powerful tool for pharmaceutical research and development. This unique molecule comprises a t-Boc-protected aminooxy moiety and a primary amine group connected via a polyethylene glycol (PEG) spacer with a length of four ethylene glycol units (PEG4).
The t-Boc-aminooxy functionality enables selective conjugation to aldehydes and ketones, forming stable oxime linkages, while the primary amine group facilitates reactions with a wide range of electrophiles, including activated esters and isothiocyanates. The PEG4 spacer imparts increased solubility and flexibility, contributing to enhanced biocompatibility and reduced immunogenicity of the resulting conjugates.
t-Boc-aminooxy-PEG4-amine serves as an indispensable reagent in the design and synthesis of complex bioconjugates, such as antibody-drug conjugates (ADCs), PEGylated proteins, and targeted drug delivery systems. By enabling site-specific conjugation and controlled release of therapeutics, this reagent has greatly expanded the scope of possibilities in drug discovery and development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
