Biotin-PEG24-TFP ester
This product is a long-chain PEG linker featuring biotin for strong avidin/streptavidin binding and a tetrafluorophenyl (TFP) ester for efficient amine conjugation. The PEG24 spacer significantly enhances solubility, hydrophilicity, and flexibility, making it especially useful for bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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Biotin Moiety: Provides high-affinity binding to avidin and streptavidin systems.
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TFP Ester: Couples efficiently with primary amines under mild conditions.
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PEG24 Spacer: Offers extended spacing, solubility, and reduced steric hindrance.
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Dual Reactivity: Supports orthogonal conjugation with high efficiency.
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High Purity: Ensures reliable performance in sensitive assays.
Applications:
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Bioconjugation: Couples biomolecules with biotin tags for detection or enrichment.
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Probe Development: Builds long-chain biotinylated probes for imaging or diagnostics.
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Drug Delivery: Enhances solubility and circulation properties in conjugates.
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Material Science: Functionalizes nanoparticles, surfaces, and polymers.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of the TFP ester.
This product combines high-affinity biotin binding with amine-reactive TFP ester chemistry, specifically offering a versatile long-chain linker for labeling, probe development, and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
