BCN-PEG1-OTs is a versatile and widely used reagent in drug research and development, particularly in the field of bioconjugation chemistry. The reagent contains a BCN group, which can selectively react with azides in a bioorthogonal “click” reaction, and a polyethylene glycol (PEG) linker, which can increase the solubility and biocompatibility of the modified molecules. The tosyl (OTs) functional group provides a leaving group for the reaction, increasing the efficiency of the bioconjugation process.
The BCN group is an alkene with a strained cyclooctene ring structure that undergoes rapid and selective reaction with azide-functionalized molecules. This “click” reaction is highly efficient, specific, and biocompatible, making it an attractive option for the site-specific modification of drugs, imaging agents, and therapeutic molecules.
The PEG linker is a flexible, hydrophilic chain that can improve the pharmacokinetic properties of the modified molecules. It can increase the solubility of the modified molecules in water, reduce their clearance by the kidneys, and improve their circulation time in the bloodstream. Additionally, the PEG linker can act as a spacer, reducing steric hindrance between the BCN group and the modified molecule and improving the accessibility of the BCN group for the azide-functionalized molecules.
The OTs functional group provides a leaving group for the reaction, increasing the efficiency of the bioconjugation process. This group can be used to introduce the BCN group onto the molecule of interest via an ester bond formation reaction, resulting in the formation of a stable and biocompatible BCN-modified molecule.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.