BCN-PEG1-OH is a versatile and widely used reagent in drug research and development, particularly in the field of bioconjugation chemistry. The reagent contains a BCN group, which can selectively react with azides in a bioorthogonal “click” reaction, and a polyethylene glycol (PEG) linker, which can increase the solubility and biocompatibility of the modified molecules.
The BCN group is an alkene with a strained cyclooctene ring structure that undergoes rapid and selective reaction with azide-functionalized molecules. This “click” reaction is highly efficient, specific, and biocompatible, making it an attractive option for the site-specific modification of drugs, imaging agents, and therapeutic molecules.
The PEG linker is a flexible, hydrophilic chain that can improve the pharmacokinetic properties of the modified molecules. It can increase the solubility of the modified molecules in water, reduce their clearance by the kidneys, and improve their circulation time in the bloodstream. Additionally, the PEG linker can act as a spacer, reducing steric hindrance between the BCN group and the modified molecule and improving the accessibility of the BCN group for the azide-functionalized molecules.
The OH functional group on BCN-PEG1-OH provides a hydroxyl group that can be used to introduce the BCN group onto the molecule of interest via an ester bond formation reaction. This reaction is commonly used to modify carboxylic acid-containing molecules, such as drugs, resulting in the formation of a stable and biocompatible BCN-modified molecule.
BCN-PEG1-OH is a valuable tool in drug research and development, offering high specificity and efficiency in the site-specific modification of drugs and other biomolecules. Its bioorthogonal “click” reaction, PEG linker, and OH functional group make it a versatile and widely used reagent for a range of applications in drug delivery, imaging, and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
