Azido-PEG3-Val-Cit-PAB-OH
This product is a cleavable linker featuring an azide for click chemistry, a Val–Cit dipeptide for protease sensitivity, and a PAB self-immolative spacer with a terminal hydroxyl. The PEG3 spacer improves solubility and flexibility, making it especially valuable for ADC design and targeted bioconjugation.
Key Features and Benefits:
-
Azide Group: Enables CuAAC and SPAAC click chemistry with alkynes.
-
Val–Cit Dipeptide: Cleaved by cathepsin B for selective drug release.
-
PAB Spacer: Self-immolative unit ensures complete payload liberation.
-
PEG3 Spacer: Provides hydrophilicity, flexibility, and compact spacing.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications:
-
ADC Development: Core linker for controlled drug release in antibody–drug conjugates.
-
Drug Delivery: Supports protease-triggered release in tumor microenvironments.
-
Bioconjugation: Combines click chemistry with enzymatic cleavage for versatile designs.
-
Probe Development: Builds protease-cleavable probes for imaging or diagnostics.
Storage and Handling:
-
Storage: Store at –20 °C, tightly sealed and protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve azide and peptide stability.
This product integrates click reactivity, protease-cleavable functionality, and a self-immolative spacer, making it an especially versatile linker for ADCs, targeted delivery, and advanced probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
