APN-Maleimide
This product is a heterobifunctional linker containing an aminopropyl nitrile (APN) group and a maleimide moiety. It enables thiol-specific conjugation and orthogonal functionalization, specifically offering compact design, solubility, and dual reactivity for bioconjugation and synthesis.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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APN Group: Provides an additional handle for orthogonal modifications.
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Compact Scaffold: Minimizes steric hindrance while maintaining reactivity.
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Dual Reactivity: Combines thiol conjugation with nitrile-based chemistry.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with orthogonal partners.
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Probe Development: Builds multifunctional probes with thiol and nitrile reactivity.
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Drug Delivery: Provides scaffolds with thiol-specific handles for targeted conjugation.
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Organic Synthesis: Serves as a versatile intermediate for modular linker chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure.
This product integrates maleimide thiol chemistry with an aminopropyl nitrile group, specifically offering compact, soluble, and multifunctional reactivity for conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
