APN-BCN
This product is a heterobifunctional linker containing an aminopropyl nitrile (APN) group and a bicyclo[6.1.0]nonyne (BCN) moiety. It specifically enables copper-free click chemistry with azides and orthogonal conjugation through the APN group, offering compact design and dual reactivity.
Key Features and Benefits
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BCN Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.
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APN Group: Provides an orthogonal functional handle for further derivatization.
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Compact Scaffold: Minimizes steric hindrance while maintaining reactivity.
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Dual Reactivity: Combines bioorthogonal click chemistry with nitrile-based modification.
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High Purity: Ensures reproducibility in bioconjugation and synthetic workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with orthogonal partners.
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Probe Development: Builds multifunctional probes with bioorthogonal and APN handles.
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Drug Delivery: Provides PEG-like scaffolds with click-ready and orthogonal reactivity.
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Organic Synthesis: Serves as a versatile intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with APN functionality in a compact scaffold, specifically offering solubility and versatile conjugation options.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
