Aminooxy-PEG7-azide
This product is a heterobifunctional PEG linker containing an aminooxy group, a PEG7 spacer, and a terminal azide. It specifically enables oxime ligation and copper-catalyzed or copper-free click chemistry, offering solubility, flexibility, and orthogonal dual reactivity.
Key Features and Benefits
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Aminooxy Group: Reacts with aldehydes or ketones to form stable oxime bonds.
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Azide Group: Couples with alkynes via CuAAC or SPAAC click chemistry.
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PEG7 Spacer: Provides solubility, hydrophilicity, and flexible spacing.
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Dual Reactivity: Combines carbonyl ligation with azide click chemistry.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links carbonyl-containing biomolecules with alkyne-modified partners.
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Probe Development: Builds multifunctional probes with orthogonal chemistries.
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Drug Delivery: Provides PEG scaffolds with aldehyde- and click-reactive groups.
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Material Science: Functionalizes polymers, nanoparticles, and surfaces with dual handles.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure.
This product integrates oxime ligation with azide click chemistry in a PEG7 scaffold, specifically offering solubility, flexibility, and multifunctionality for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
