Amino-PEG5-t-butyl ester
This product is a heterobifunctional linker containing a primary amine, a PEG5 spacer, and a protected t-butyl ester. The amine enables conjugation to activated esters or carboxyl groups, while the t-butyl ester can be deprotected under mild acidic conditions to yield a free acid for further coupling. The PEG5 chain specifically enhances solubility and flexibility, reducing steric hindrance in conjugation.
Key Features and Benefits
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Primary Amine: Couples efficiently with activated esters and carboxylic acids.
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t-Butyl Ester: Protects the acid terminus until selective deprotection.
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PEG5 Spacer: Improves solubility, flexibility, and accessibility.
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Dual Reactivity: Supports stepwise conjugation strategies.
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High Purity: Produced to ≥95% purity for reliable and reproducible results.
Applications
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Bioconjugation: Links biomolecules through amine and carboxyl chemistry.
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Drug Delivery: Serves as an intermediate for PEGylated therapeutics and carriers.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Organic Synthesis: Acts as a versatile scaffold for PEG-based derivatives.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Deprotect t-butyl ester under mild acidic conditions when required; prepare fresh solutions before use.
This product provides amine reactivity with a protected acid terminus on a PEG5 backbone, specifically offering a versatile linker for stepwise synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
