Amino-PEG4-tris-PEG4-alkyne
This product is a multifunctional PEG reagent with a primary amine at one end and a tris-alkyne group connected by PEG4 spacers. The design specifically provides hydrophilicity, flexibility, and multiple alkyne handles for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Key Features and Benefits:
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Amine Group: Reacts with carboxyls, NHS esters, and other electrophiles.
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Tris-Alkyne Functionality: Enables multivalent click chemistry with azides.
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PEG4 Spacers: Improve solubility, flexibility, and reduce steric hindrance.
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High Purity: Reliable for reproducible bioconjugation results.
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Versatile: Works in both aqueous and organic systems.
Applications:
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Click Chemistry: Multivalent conjugation with azide-bearing biomolecules.
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Bioconjugation: Link proteins, peptides, or polymers with spatial control.
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Drug Delivery: Spacer-linker for multivalent payload attachment.
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Surface Modification: Functionalize nanoparticles, hydrogels, or polymers with multiple alkyne handles.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve amine and alkyne reactivity.
This product provides a reactive amine and multivalent alkyne groups on PEG spacers, making it an especially powerful tool for multivalent click chemistry and advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
