Amino-PEG24-t-butyl ester
This product is a long-chain, heterobifunctional PEG reagent with a terminal primary amine and a t-butyl ester group connected by a PEG24 spacer. The PEG chain specifically improves solubility and flexibility, while the t-butyl ester provides acid-labile protection for orthogonal conjugation strategies.
Key Features and Benefits:
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Amine Functionality: Enables coupling with carboxyls, NHS esters, or other electrophiles.
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t-Butyl Ester Protection: Acid-labile group allows selective deprotection and staged synthesis.
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PEG24 Spacer: Enhances solubility, reduces steric hindrance, and provides extended spacing.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Versatile Chemistry: Compatible with aqueous and organic reactions.
Applications:
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Bioconjugation: Site-specific coupling of proteins, peptides, and other biomolecules.
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Drug Delivery: Spacer-linker to improve solubility and pharmacokinetics.
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Surface Modification: Functionalization of nanoparticles, hydrogels, or biosensors.
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Material Science: PEGylation of polymers and advanced biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve amine and ester integrity.
This product combines a reactive amine, acid-labile ester protection, and long-chain PEG spacing, making it an especially excellent tool for advanced conjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
