Amino-PEG24-CH2CO2-t-butyl ester
Amino-PEG24-CH2CO2-t-butyl ester is a high-purity, monodisperse PEG reagent with a primary amine for versatile coupling and a tert-butyl ester–protected carboxyl group for selective deprotection. The long PEG24 spacer greatly enhances aqueous solubility, flexibility, and reduces steric hindrance, enabling efficient conjugation in both aqueous and organic media. This reagent is ideal for orthogonal functionalization strategies in bioconjugation, drug delivery, and surface modification.
Key Features and Benefits
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Primary Amine – Enables coupling with NHS esters, activated acids, isocyanates, and other electrophiles.
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t-Butyl Ester Protection – Acid-labile protection for the carboxyl group, allowing selective deprotection under mild acidic conditions.
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PEG24 Spacer – Significantly improves water solubility, provides high flexibility, and minimizes steric hindrance between reactive groups.
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Orthogonal Reactivity – Supports sequential functionalization of amine and carboxyl groups.
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High Purity – Supplied at >95% purity for consistent performance in sensitive applications.
Applications
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Bioconjugation and crosslinking
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Protein, peptide, and small molecule modification
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Surface and nanoparticle functionalization
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Antibody–drug conjugate (ADC) linker design
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Drug delivery systems requiring orthogonal protection strategies
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve amine reactivity and ester protection
This product offers a primary amine for coupling and a t-butyl–protected carboxyl group for orthogonal deprotection, with an extended PEG24 spacer for optimal solubility and flexibility. It is especially ideal for stepwise functionalization in advanced bioconjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
