Amino-PEG12-CH2CO2-t-butyl ester
Amino-PEG12-CH2CO2-t-butyl ester is a high-purity, monodisperse PEG reagent with a primary amine for versatile coupling and a tert-butyl ester-protected carboxyl group for selective deprotection. The long PEG12 spacer significantly improves aqueous solubility, flexibility, and reduces steric hindrance, enabling efficient conjugation in both aqueous and organic media. This reagent is ideal for stepwise functionalization strategies where orthogonal protection is required.
Key Features and Benefits
-
Primary Amine – Enables coupling with NHS esters, activated acids, isocyanates, and other electrophiles.
-
t-Butyl Ester Protection – Acid-labile protection for the carboxyl group, allowing orthogonal deprotection under mild acidic conditions.
-
PEG12 Spacer – Enhances water solubility, increases molecular flexibility, and reduces steric hindrance.
-
Orthogonal Reactivity – Allows sequential functionalization of amine and carboxyl groups.
-
High Purity – Supplied at >95% purity for reproducible results in sensitive applications.
Applications
-
Bioconjugation and crosslinking
-
Peptide, protein, and small molecule modification
-
Surface functionalization and polymer modification
-
ADC and drug delivery research requiring orthogonal protection strategies
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light
-
Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture
This product offers a primary amine for coupling and a t-butyl-protected carboxyl group for orthogonal deprotection, with a PEG12 spacer for optimal solubility and flexibility, making it especially ideal for stepwise functionalization in bioconjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
