Amino-PEG1-t-butyl ester
This product is a compact PEG linker with a terminal amine, a single ethylene glycol unit, and a tert-butyl ester. The amine reacts readily with carboxyls or NHS esters to form stable amides, while the tert-butyl ester protects a carboxyl group for controlled deprotection. Its short PEG1 spacer adds minimal solubility and spacing, making this reagent especially ideal for compact conjugation strategies.
Key Features and Benefits
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Amine Group: Couples efficiently with carboxyls or NHS esters.
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t-Butyl Ester: Protects a carboxyl group for orthogonal deprotection.
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PEG1 Spacer: Provides minimal spacing with slight solubility enhancement.
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Compact Design: Reduces steric hindrance in tight conjugation environments.
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High Purity: Produced to ≥95% purity for consistent results.
Applications
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Bioconjugation: Links biomolecules with controlled orthogonal chemistry.
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Protein and Antibody Labeling: Supports compact modifications.
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Drug Delivery: Serves as a modular protected PEG linker.
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Probe Development: Builds intermediates for multifunctional probes.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove t-butyl ester under mild acidic conditions; prepare fresh solutions.
This product combines a reactive amine and protected ester in a compact PEG scaffold, specifically offering precision for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
