Ald-CH2-PEG3-Propargyl (CAS: 2249926-66-5)
Ald-CH2-PEG3-Propargyl serves as a versatile bifunctional PEG linker with an aldehyde group and a propargyl (alkyne) group. The aldehyde group forms covalent bonds with aminooxy or hydrazine-functionalized targets, while the propargyl group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), commonly referred to as “click chemistry.” Additionally, its PEG₃ spacer improves solubility, enhances flexibility, and minimizes steric hindrance during complex bioconjugation reactions.
Key Features:
- Reactive Groups:
- Aldehyde (-CHO): Forms stable covalent bonds with aminooxy or hydrazine groups, supporting biomolecule attachment.
- Propargyl (Alkyne): Participates in CuAAC reactions, enabling efficient bioconjugation with azide-containing compounds.
- PEG₃ Spacer:
- Enhances solubility in aqueous environments.
- Increases molecular flexibility, reducing steric interference during conjugation.
Applications:
- Bioconjugation:
- Facilitates the attachment of biomolecules such as peptides, proteins, and antibodies through aldehyde-amine and alkyne-azide linkages.
- Drug Development:
- Functions as a key linker in the synthesis of complex therapeutic molecules, enhancing their stability and bioavailability.
Handling and Storage:
- Molecular Formula: C₉H₁₄O₄
- Molecular Weight: 186.21 g/mol
- Storage Recommendations:
- Store in a cool, dry environment, protected from light and moisture, to maintain product stability.
Overall, Ald-CH2-PEG3-Propargyl offers a powerful combination of reactivity, flexibility, and solubility. Its dual-reactive design makes it essential for bioconjugation, click chemistry, and advanced drug development applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.