Ald-CH2-PEG3-NHBoc

Ald-CH2-PEG3-NHBoc

Ald-CH2-PEG3-NHBoc is a high-purity heterobifunctional PEG linker with an aldehyde group for oxime or hydrazone ligation and a Boc-protected amine for controlled activation. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient bioconjugation in both aqueous and organic systems. The Boc group keeps the amine protected until mild acidic deprotection is performed, allowing orthogonal, stepwise conjugation strategies.

Key Features and Benefits

• Aldehyde Group: Reacts with hydrazides and aminooxy groups to form stable oxime or hydrazone bonds.

• Boc-Protected Amine: Stable under neutral and basic conditions; deprotected under mild acidic conditions to reveal a primary amine.

• PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.

• Heterobifunctional Design: Enables orthogonal and sequential modification strategies.

• High Purity: Supplied at >95% purity for reproducible and consistent results.

Applications

• Stepwise Bioconjugation: Protect the amine until later in the synthesis for controlled functionalization.

• Protein and Peptide Modification: Attach aldehyde-reactive handles before amine activation.

• Nanoparticle and Surface Functionalization: Introduce aldehyde groups with latent amine functionality.

• Drug Delivery Systems: Enable sequential payload attachment with controlled activation steps.

• Diagnostic and Imaging Probes: Prepare multifunctional probes with orthogonal chemistries.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.

Ald-CH2-PEG3-NHBoc combines aldehyde reactivity with a protected amine in a hydrophilic PEG3 framework, specifically offering flexibility for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.