Ald-benzyl-amine-PEG2-TCO
This product is a bifunctional linker combining an aldehyde-reactive benzyl amine with a trans-cyclooctene (TCO) handle. The PEG2 spacer improves solubility and flexibility, making it especially ideal for rapid ligation, probe development, and bioorthogonal chemistry.
Key Features and Benefits
-
Aldehyde-Reactive Amine: Couples efficiently with aldehydes to form stable imine or reductive amination linkages.
-
TCO Handle: Enables ultrafast inverse electron-demand Diels–Alder (IEDDA) click reactions with tetrazines.
-
PEG2 Spacer: Enhances solubility and reduces steric hindrance in conjugation workflows.
-
Bifunctional Design: Combines aldehyde chemistry with TCO click reactivity for orthogonal strategies.
-
High Purity: Produced to ≥95% purity for consistent performance in research applications.
Applications
-
Bioconjugation: Links aldehyde-containing biomolecules with tetrazine-functionalized partners through dual reactivity.
-
Probe Development: Builds dual-functional imaging and therapeutic probes for chemical biology.
-
Drug Delivery Research: Supports conjugation of aldehyde-bearing drugs with tetrazine-labeled carriers.
-
Orthogonal Chemistry: Enables multi-step synthetic pathways with independent functional groups.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, dry container, protected from light.
-
Handling: Use under inert atmosphere when possible; avoid prolonged exposure to heat and moisture.
This product integrates aldehyde-reactive amine chemistry with TCO click functionality, providing an especially versatile tool for orthogonal conjugation and advanced bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
