Ald-benzoylamide-PEG2-CH2 NHS ester
This high-purity heterobifunctional PEG linker features a terminal aldehyde for chemoselective oxime or hydrazone ligation with aminooxy or hydrazide groups, and an NHS ester for efficient coupling to primary amines. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, specifically enabling efficient, orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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Aldehyde Group – Enables selective oxime or hydrazone formation with aminooxy or hydrazide moieties.
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NHS Ester – Facilitates rapid, efficient amine coupling under mild conditions.
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PEG2 Spacer – Enhances solubility and accessibility of reactive groups while minimizing steric hindrance.
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Orthogonal Reactivity – Supports sequential, site-specific conjugation strategies.
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High Purity – Supplied at >95% purity for consistent performance.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and antibody modification
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Multifunctional probe and drug conjugate synthesis
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Targeted delivery systems
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines aldehyde-mediated ligation with NHS–amine coupling, linked by PEG2 for solubility and flexibility, especially ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
