Acid-PEG4-t-butyl ester
This product is a heterobifunctional PEG linker featuring a terminal carboxylic acid and an acid-labile t-butyl ester. The PEG4 spacer improves solubility and flexibility, making it especially ideal for orthogonal conjugation, drug delivery, and advanced bioconjugation applications.
Key Features and Benefits:
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Carboxylic Acid: Couples efficiently with primary amines for stable amide bonds.
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t-Butyl Ester: Provides acid-labile protection for stepwise synthesis.
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PEG4 Spacer: Enhances solubility and steric accessibility.
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Orthogonal Reactivity: Supports controlled conjugation strategies.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Builds multifunctional PEGylated conjugates with protected handles.
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Drug Delivery: Provides orthogonal linkers for targeted systems.
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Probe Development: Useful in diagnostic probe synthesis.
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Synthetic Chemistry: Serves as an intermediate for orthogonal strategies.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature ester cleavage.
This product combines a reactive acid and protected ester in a PEG4 scaffold, specifically offering solubility and orthogonal control for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
