Acid-PEG3-mono-methyl ester
This product is a heterobifunctional PEG linker with a free carboxylic acid at one end and a methyl ester at the other, separated by a PEG3 spacer. The acid allows amide bond formation with primary amines, while the methyl ester provides a protected carboxyl group that can be hydrolyzed for further functionalization. The PEG3 chain specifically enhances solubility and flexibility, making this a versatile intermediate for bioconjugation and synthetic chemistry.
Key Features and Benefits
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Carboxylic Acid Group: Couples readily with amines through amide bond formation.
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Methyl Ester Group: Acts as a protected acid, hydrolyzable under mild conditions for additional derivatization.
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PEG3 Spacer: Improves solubility, reduces steric hindrance, and enhances accessibility.
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Heterobifunctional Design: Offers dual reactivity for stepwise conjugation strategies.
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High Purity: Manufactured to ≥95% purity for reproducibility in research workflows.
Applications
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Bioconjugation: Couples biomolecules, peptides, or drugs via amide or ester chemistry.
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Probe Development: Serves as a precursor for multifunctional imaging and diagnostic probes.
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Drug Delivery: Functions as a PEGylation linker for therapeutics and nanocarriers.
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Organic Synthesis: Acts as a flexible intermediate for multifunctional PEG derivatives.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare solutions fresh before use; avoid repeated freeze–thaw cycles.
This product combines a reactive acid, a protected ester, and a solubilizing PEG spacer, specifically offering a compact and versatile tool for stepwise bioconjugation and synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
