Acid-PEG2-NHS ester
This high-purity heterobifunctional PEG linker features a terminal carboxylic acid for amide coupling to amines or other nucleophiles, and an NHS ester for rapid, efficient conjugation to primary amines under mild conditions. The PEG2 spacer specifically improves solubility, flexibility, and reduces steric hindrance, enabling efficient and orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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Carboxylic Acid Group – Enables versatile amide coupling to a wide range of nucleophiles.
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NHS Ester – Reacts rapidly and selectively with primary amines under mild conditions.
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PEG2 Spacer – Enhances solubility and accessibility of reactive groups while minimizing steric hindrance.
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Orthogonal Reactivity – Suitable for sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible results.
Applications
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Protein, peptide, and antibody modification
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Dual-functional linker for orthogonal conjugation
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Antibody–drug conjugate (ADC) linker chemistry
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Multifunctional imaging and diagnostic probe synthesis
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product links carboxyl and NHS ester reactivities through PEG2 for enhanced solubility and flexibility, especially ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
