What is 5-BDBD: Potent P2X4 Receptor Antagonist
5-BDBD (CAS: 768404-03-1) is a potent and selective P2X4 receptor antagonist with an IC50 of 0.75 μM. It directly inhibits rP2X4R-mediated currents and blocks both basal and nitroglycerin-induced hyperalgesia. This makes it a key compound for research into pain and inflammation.
Applications:
- Chronic Pain Research:
5-BDBD blocks P2X4 receptors, which play a major role in neuropathic pain. By stopping nitroglycerin-induced hyperalgesia, it helps researchers develop better treatments for chronic pain. - Inflammation Studies:
P2X4 receptors regulate immune response. With 5-BDBD inhibiting these receptors, researchers can explore inflammation inhibitors and investigate anti-inflammatory therapies more effectively. - Cardiovascular Research:
P2X4 receptors affect heart function and blood pressure. Using 5-BDBD, researchers study its role in cardiovascular conditions like hypertension, improving our understanding of these diseases. - Neurodegenerative Disease:
In diseases like Alzheimer’s, P2X4 receptors on microglia increase neuroinflammation. It allows researchers to find new ways to treat neurodegenerative diseases through selective P2X4 inhibition.
Conclusion:
5-BDBD’s ability to block P2X4 receptor functions makes it invaluable in pain, inflammation, cardiovascular, and neurodegenerative disease research. Its targeted action provides crucial insights, driving the development of new therapies.
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