4-Methyl-4-(pyridin-2-yldisulfaneyl)pentanoic acid
This product is a high-purity thiol-reactive reagent featuring a pyridyl disulfide group and a terminal carboxylic acid. The pyridyl disulfide moiety enables selective and efficient disulfide exchange with thiols, releasing pyridine-2-thione as a byproduct, while the carboxylic acid allows further coupling to amines via carbodiimide or active ester chemistry, especially ideal for introducing cleavable disulfide linkages in bioconjugates, crosslinkers, and drug delivery systems.
Key Features and Benefits
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Pyridyl Disulfide Group: Enables selective thiol–disulfide exchange with measurable release of pyridine-2-thione.
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Carboxylic Acid: Couples efficiently to amines for stable amide bond formation.
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Cleavable Linkage: Disulfide bond allows controlled release under reducing conditions.
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High Purity: Supplied at >95% purity for reproducible results.
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Versatile Utility: Compatible with aqueous and organic reaction conditions.
Applications
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Thiol-specific protein and peptide modification.
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Synthesis of cleavable linkers for drug delivery.
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Preparation of reducible crosslinkers in biomaterials.
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Site-specific labeling in biochemical assays.
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Development of controlled-release bioconjugates.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents; avoid prolonged exposure to reducing agents.
This product combines thiol–disulfide exchange reactivity with a carboxylic acid handle for amide coupling, specifically enabling cleavable linker design in bioconjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
