3,4-Dibromo-Mal-PEG2-Boc-Amine
This high-purity heterobifunctional PEG linker features a 3,4-dibromomaleimide group for selective thiol conjugation via Michael addition and a Boc-protected amine for orthogonal deprotection under mild acidic conditions. The PEG2 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient and site-specific bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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3,4-Dibromomaleimide Group – Reacts selectively with thiols for stable conjugation.
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Boc-Protected Amine – Allows controlled, orthogonal deprotection for sequential coupling.
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PEG2 Spacer – Improves solubility and reduces steric hindrance.
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High Purity – Supplied at >95% purity for reproducible results.
Applications
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Protein and peptide modification
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Antibody–drug conjugates (ADCs)
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Site-specific dual conjugation strategies
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Multifunctional probe and therapeutic development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure.
This product enables thiol conjugation and protected amine chemistry with a PEG2 spacer for solubility and flexibility, especially ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
