2′-O-Me-C(Bz) Phosphoramidite (CAS: 110764-78-8): Overview and Applications
2′-O-Me-C(Bz) Phosphoramidite (CAS: 110764-78-8) is a modified nucleotide used in oligonucleotide synthesis. It features a 2′-O-methyl (Me) modification and a benzoyl (Bz) group on cytidine (C), enhancing the stability and functionality of RNA sequences.
Key Features:
- 2′-O-Methyl Group: Protects the 2′ hydroxyl, improving stability against nucleases and enhancing overall resistance to degradation.
- Benzoyl Group: Stabilizes the amine group at the N4 position of cytidine, increasing the effectiveness of nucleotide incorporation.
Applications:
- Oligonucleotide Synthesis: Ideal for synthesizing stable RNA sequences with modified bases.
- Gene Expression Studies: Used in probes and primers for analyzing RNA expression and regulation.
- Antisense Oligonucleotides: Provides enhanced stability for therapeutic applications targeting RNA.
- Diagnostics: Supports the development of RNA-based diagnostic assays.
2′-O-Me-C(Bz) Phosphoramidite is essential for creating modified oligonucleotides in research, diagnostics, and therapeutic development.
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