2′-O-Me-C(Bz) Phosphoramidite
This product is a cytidine phosphoramidite modified with a 2′-O-methyl group and a benzoyl (Bz) base-protecting group. This reagent enhances nuclease resistance, duplex stability, and synthetic yield, specifically used in oligonucleotide synthesis and therapeutic nucleic acid development.
Key Features and Benefits:
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2′-O-Methyl Modification: Increases nuclease resistance and hybridization affinity.
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Benzoyl Protection: Ensures controlled base protection during automated synthesis.
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High Purity: Optimized for solid-phase oligonucleotide synthesis.
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Improved Stability: Enhances RNA duplex stability and reduces degradation.
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Industry Standard: Compatible with DNA/RNA synthesizers for reliable incorporation.
Applications:
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Oligonucleotide Synthesis: Incorporation of 2′-O-Me cytidine residues into RNA/DNA.
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Therapeutic Development: Used in antisense oligonucleotides, siRNA, and aptamers.
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Research Tools: Ideal for probe design, diagnostics, and functional genomics.
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Structural Studies: Supports modification of nucleic acids for stability testing.
Storage and Handling:
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Storage: Store at –20 °C under inert atmosphere, protected from light and moisture.
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Handling: Use standard phosphoramidite synthesis protocols in acetonitrile.
This product combines stability, high incorporation efficiency, and nuclease resistance, making it a key building block specifically for advanced oligonucleotide synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
