HyNic-PEG2-Amino-DBCO
This product is a multifunctional PEG linker containing a hydrazinonicotinamide (HyNic) group, a PEG2 spacer, a primary amine, and a dibenzocyclooctyne (DBCO). It specifically enables copper-free click chemistry, aldehyde coupling, and amide conjugation in one versatile scaffold.
Key Features and Benefits
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HyNic Group: Couples with aldehydes and ketones to form stable hydrazone bonds.
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DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Primary Amine: Couples with carboxyls, NHS esters, or activated linkers.
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PEG2 Spacer: Enhances solubility and reduces steric hindrance.
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Multifunctional Reactivity: Provides three orthogonal reactive handles for advanced conjugation strategies.
Applications
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Bioconjugation: Links biomolecules through aldehyde, amine, or azide–alkyne click chemistry.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with multiple conjugation handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with orthogonal chemistries.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates hydrazone chemistry, copper-free click reactivity, and amide coupling in a PEG2 scaffold, specifically providing powerful multifunctionality for advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
