TCO-PEG1-Br is a chemical reagent used in bioconjugation and biomaterials development. This reagent contains a trans-cyclooctene (TCO) functional group, a polyethylene glycol (PEG) spacer of one unit, and a bromine atom.
The TCO functional group in TCO-PEG1-Br can react with complementary tetrazine-containing molecules via a fast and selective bioorthogonal reaction. This reaction is commonly referred to as the “click-to-release” reaction and is widely used in the development of targeted drug delivery systems and imaging agents.
The PEG1 spacer in this reagent provides hydrophilicity, flexibility, and biocompatibility, which can reduce non-specific interactions with biomolecules and improve the solubility and stability of the bioconjugate.
The bromine atom in TCO-PEG1-Br is commonly used as a leaving group for substitution reactions, and can be replaced with other functional groups or biomolecules. This allows for further modification of the bioconjugate, including the addition of targeting ligands, imaging agents, or therapeutic payloads.
TCO-PEG1-Br has been used in a variety of biological applications, including the modification of proteins, peptides, and antibodies for targeted drug delivery and imaging, as well as the functionalization of surfaces and biomaterials.
When working with TCO-PEG1-Br, it is important to handle it with care, as it can be potentially hazardous. Proper protective equipment, including gloves and a lab coat, should be worn, and the reagent should be stored according to the manufacturer’s instructions. Additionally, it is important to follow appropriate disposal procedures for the reagent and any materials contaminated with it.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
