Mal-PEG2-BocNH Tyrosine Methyl Ester is a chemical reagent that is widely used in the field of peptide synthesis. It is a derivative of tyrosine, which is an amino acid that is frequently incorporated into peptides due to its aromatic properties and ability to participate in hydrogen bonding.
The reagent consists of a tyrosine residue that has been protected with a Boc (tert-butoxycarbonyl) group to prevent unwanted reactions from occurring during the synthesis process. Additionally, a maleimide (Mal) group has been added to the tyrosine residue, which can react with sulfhydryl groups in proteins or other biomolecules to form covalent bonds. A PEG (polyethylene glycol) linker has also been added to the Boc-protected tyrosine residue to increase its solubility in water and enhance its overall stability.
Mal-PEG2-BocNH Tyrosine Methyl Ester is often used as a building block in the synthesis of peptides and other biologically active molecules. It can be incorporated into a peptide chain through solid-phase synthesis or solution-phase synthesis methods, depending on the specific application. Once the peptide has been synthesized, the Boc protecting group can be removed under appropriate conditions to expose the free amine group, which can then be used for further chemical modification or bioconjugation.
The presence of the maleimide group in Mal-PEG2-BocNH Tyrosine Methyl Ester makes it a useful reagent for bioconjugation applications. The maleimide group is highly reactive toward sulfhydryl groups on proteins or other biomolecules, allowing for the formation of covalent bonds between the peptide and the target molecule. The PEG linker enhances the water solubility and stability of the reagent, making it a valuable tool for the synthesis of complex and functionalized peptides.
Mal-PEG2-BocNH Tyrosine Methyl Ester is a versatile and useful reagent for the synthesis of peptides and related molecules. Its unique properties make it an attractive option for a variety of applications in both academic and industrial settings. The presence of the maleimide group provides a convenient handle for bioconjugation, and the PEG linker enhances its solubility and stability in water. Overall, it is a valuable tool for the synthesis of complex and functionalized peptides, particularly those intended for biological applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
