Propargyl-PEG1-BocNH Tyrosine Methyl Ester
This product is a multifunctional protected amino acid derivative containing a propargyl group, PEG1 spacer, Boc-protected amine, and tyrosine methyl ester. It specifically enables click chemistry, staged deprotection, and peptide synthesis.
Key Features and Benefits
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Propargyl Group: Reacts efficiently with azides via CuAAC or SPAAC click chemistry.
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Boc-Protected Amine: Allows orthogonal deprotection for controlled conjugation.
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Tyrosine Methyl Ester: Preserves aromatic side-chain functionality in synthesis.
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PEG1 Spacer: Enhances solubility and provides compact spacing.
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Multifunctional Design: Combines click, amine, and ester chemistry in one scaffold.
Applications
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Peptide Synthesis: Serves as a multifunctional protected building block.
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Bioconjugation: Links biomolecules using click and amide chemistry.
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Probe Development: Builds multifunctional probes with orthogonal handles.
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Medicinal Chemistry: Supports design of multifunctional drug intermediates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature Boc removal or hydrolysis.
This product integrates click reactivity with staged protecting groups in a PEG1 scaffold, specifically offering multifunctional versatility for peptide and probe synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
