t-Boc-N-Amido-PEG4-acid (Boc-NH-PEG4-acid or BocNH-PEG4-CH2CH2COOH) (CAS# 756525-91-4) is a bifunctional molecule used in peptide synthesis and bioconjugation. It contains a Boc-protected amino group and a terminal carboxylic acid. The PEG4 spacer increases the compound’s solubility in water.
Key Features:
- Terminal Carboxylic Acid: This group reacts easily with primary and secondary amines using coupling agents like EDC, DCC, or HATU to form stable amide bonds.
- Boc Protection: The t-Boc group protects the amino group. You can remove it under mild acidic conditions, which exposes the free amine for further reactions.
t-Boc-N-Amido-PEG4-acid Applications:
- Peptide Synthesis: The protected amino group allows for stepwise synthesis while keeping the terminal carboxylic acid available for reactions.
- Bioconjugation: The terminal carboxylic acid links with biomolecules via amide bonds, enhancing their effectiveness.
- Surface Modification: The PEG spacer improves interactions with biological systems, making the compound more versatile.
- Drug Delivery Systems: PEGylated compounds boost solubility and circulation time, making them ideal for drug formulations.
Overall, BocNH-PEG4-CH2CH2COOH is a versatile compound that supports precise chemical modifications in both peptide synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
