Hoechst S769121 (Nuclear Yellow, CAS: 74681-68-8) is a yellow-emitting fluorescent dye that binds to adenine-thymine-rich regions of DNA, making it ideal for nuclear staining. It is commonly used in fluorescence microscopy, flow cytometry, and neuronal imaging due to its strong DNA-binding properties and distinct fluorescence.
Key Features:
- DNA Binding: Targets AT-rich regions in double-stranded DNA for strong nuclear staining.
- Yellow Fluorescence: Excitation at ~360 nm and emission at ~505 nm, producing bright yellow fluorescence.
- Dual Imaging Compatibility: Often paired with other tracers like True Blue for multi-color imaging.
Hoechst S769121 Applications:
- Fluorescence Microscopy: Stains nuclear DNA in live or fixed cells for cell structure analysis.
- Flow Cytometry: Measures DNA content for cell cycle and apoptosis studies.
- Neuronal Imaging: Maps neural networks when used with retrograde tracers.
- Electron Microscopy: Photoconverts DAB into an electron-dense product, enabling light and electron microscopy.
Handling and Storage:
- Solubility: Easily dissolves in water and DMSO.
- Storage: Store at -20°C, protected from light, to ensure long-term stability.
Hoechst S769121 is a versatile tool for cell biology, neuroscience, and molecular imaging, offering reliable DNA staining and multi-modal compatibility.
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