Fmoc-L-Lys-DOTAM provides a functionalized amino acid building block for peptide synthesis, metal coordination, and molecular imaging research and specifically combines an Fmoc-protected L-lysine scaffold with a DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide) macrocyclic chelating group. This structure specifically supports incorporation of DOTAM functionality into peptide-based constructs for coordination chemistry and biomedical research.
Key Features and Benefits
- DOTAM Macrocyclic Framework: Features a tetraazacyclododecane-based chelator with four acetamide donor groups specifically for coordination of suitable metal ions.
- Fmoc-Protected Amino Acid: Contains an Fmoc-protected α-amino group compatible with standard Fmoc-based peptide synthesis strategies.
- L-Lysine Scaffold: Provides a chiral amino acid framework specifically for incorporating DOTAM functionality into peptides and related biomolecules.
- Peptide Synthesis Compatibility: Supports incorporation into peptide sequences through appropriately optimized solid-phase peptide synthesis procedures.
- Metal Coordination Capability: The DOTAM macrocycle supports investigation of lanthanide and other compatible metal complexes.
- Functionalized Lysine Side Chain: Enables introduction of a macrocyclic chelating group specifically through the lysine residue within peptide-based constructs.
- Fmoc Deprotection Compatibility: Allows removal of the Fmoc protecting group under suitable basic conditions for subsequent peptide coupling reactions.
- Versatile Research Applications: Supports development of metal-binding peptides, molecular probes, and functionalized biomolecular systems.
Applications
- Solid-Phase Peptide Synthesis: Supports incorporation of DOTAM-functionalized lysine residues into synthetic peptides using Fmoc-based strategies.
- Chelator-Modified Peptides: Enables preparation of peptide constructs containing macrocyclic metal coordination sites.
- Lanthanide Coordination Research: Useful for investigating DOTAM complexation with compatible lanthanide ions and their coordination properties.
- Molecular Imaging Research: Supports development of metal-chelate peptide constructs for investigational imaging applications.
- MRI Contrast Agent Research: Useful for exploring DOTAM-based coordination systems and their potential magnetic resonance properties.
- Peptide Bioconjugation: Enables introduction of DOTAM functionality into peptides for subsequent metal complexation and molecular modification.
- Coordination Chemistry Studies: Supports investigation of metal-binding behavior, coordination geometry, and complex stability.
- Biomolecular Probe Development: Useful for preparing functionalized peptides containing metal-binding groups for analytical and biological research.
- Peptide Structure-Function Studies: Supports evaluation of how DOTAM-modified lysine residues influence peptide properties and molecular interactions.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container unless otherwise specified. Protect from moisture, excessive heat, and prolonged light exposure.
- Handling: Handle under dry conditions using appropriate laboratory precautions. For peptide synthesis, use suitable coupling reagents and Fmoc deprotection conditions. Optimize reaction conditions to preserve the DOTAM framework and minimize unwanted side reactions.
Fmoc-L-Lys-DOTAM combines an Fmoc-protected L-lysine building block with a DOTAM macrocyclic chelator for peptide functionalization and specifically supports solid-phase peptide synthesis, metal coordination, molecular imaging research, and development of chelator-modified biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
