2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester), CAS Number 173308-19-5, is a bioconjugation agent commonly used for radiolabeling and molecular imaging.
Overview
- Full Name: 2-Aminoethyl-mono-amide-DOTA-tris (tert-butyl ester).
- CAS Number: 173308-19-5.
- Chemical Formula: C23H44N5O7.
- Molecular Weight: 501.63 g/mol.
Key Applications
- Bioconjugation: The aminoethyl group provides a reactive site for attaching to biomolecules like peptides, proteins, and antibodies.
- Radiolabeling: DOTA acts as a chelator, binding metal ions such as Gallium-68 for PET imaging or Yttrium-90 for targeted therapy.
- Imaging: It is used to develop stable imaging agents for PET, SPECT, and MRI, aiding diagnostics in biomedical research.
Properties
- Aminoethyl Group: Offers a straightforward attachment point for bioconjugation with various molecules.
- tert-Butyl Ester Protection: Protects the DOTA’s carboxyl groups during synthesis, ensuring stability until deprotection for metal chelation.
- Chelating Power: DOTA provides strong binding to metal ions, which enhances the stability of radiolabeled compounds.
Handling and Storage
- Storage: Store in a cool, dry place, away from light to preserve reactivity.
- Handling: Use protective equipment to prevent unintended reactions during synthesis.
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