p-NO₂-Bn-DOTA, CAS Number 116052-88-1, is a specialized chelating agent commonly used for bioconjugation, radiolabeling, and molecular imaging.
Overview
- Full Name: p-Nitrobenzyl-DOTA.
- CAS Number: 116052-88-1.
- Chemical Formula: C18H25N3O8.
- Molecular Weight: 411.41 g/mol.
p-NO₂-Bn-DOTA Applications
- Bioconjugation: The nitro group (NO₂) allows further chemical modifications, making it suitable for linking to various biomolecules.
- Radiolabeling: DOTA acts as a powerful chelator, binding metal ions such as Gallium-68 (Ga-68) for PET imaging or Lutetium-177 (Lu-177) for targeted therapy.
- Imaging: Frequently used in creating imaging agents for PET, SPECT, and MRI, supporting advanced diagnostic methods in biomedical research.
Properties
- Nitro Group (NO₂): Provides a site for chemical modification, enabling the introduction of other functional groups.
- Chelating Power: DOTA forms stable complexes with metal ions, ensuring effective and reliable radiolabeling for diagnostic purposes.
Handling and Storage
- Storage: Store in a cool, dry place, protected from light to preserve stability.
- Handling: Use standard protective measures to avoid unwanted reactions during synthesis.
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