m-PEG-GAS, MW 1K
This product is a monofunctional PEG derivative featuring a terminal NHS ester and a methoxy group on the opposite end. The NHS ester reacts efficiently with primary amines to form stable amide bonds, while the methoxy capping prevents undesired crosslinking. The 1 kDa PEG chain provides hydrophilicity, flexibility, and improved solubility, making this reagent especially useful for PEGylation and bioconjugation.
Key Features and Benefits
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NHS Ester: Reacts with primary amines for stable amide bond formation.
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Methoxy End-Cap: Prevents crosslinking, ensuring controlled modification.
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PEG (1K): Provides hydrophilicity, flexibility, and moderate chain length.
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Biocompatible Design: Enhances solubility and reduces immunogenicity.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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PEGylation: Conjugates proteins, peptides, and small molecules for improved stability.
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Bioconjugation: Couples biomolecules via amine-reactive chemistry.
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Drug Delivery: Extends circulation time of therapeutics.
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Material Science: Functionalizes surfaces and polymers with PEG units.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Dissolve freshly in dry organic solvents; avoid repeated freeze–thaw cycles.
This product offers efficient amine-reactivity and biocompatible PEGylation in a compact 1 kDa scaffold, making it an especially versatile reagent for biomolecule and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
