2′-O-MOE-C(Bz)-3′-phosphoramidite, CAS 251647-54-8, is a modified nucleoside used in oligonucleotide synthesis. It features a 2′-O-methoxyethyl (MOE) modification, which boosts the stability and binding affinity of oligonucleotides. The benzoyl (Bz) protection on the cytosine ensures smooth incorporation during synthesis. Researchers often use this reagent for antisense oligonucleotides, RNA therapeutics, and other nucleic acid applications.
Key Features
- 2′-O-MOE Modification: Increases oligonucleotide stability and binding strength, making them more resistant to nuclease degradation.
- Benzoyl-Protected Cytosine: Allows efficient coupling during synthesis, maintaining nucleobase integrity.
- Phosphoramidite Compatibility: Integrates easily with standard DNA/RNA synthesis protocols.
Applications
- Antisense Oligonucleotides: Enhances stability and effectiveness for therapeutic use.
- RNA Therapeutics: Improves pharmacokinetic properties in RNA-based drugs.
- Nucleic Acid Research: Suitable for studying interactions, structures, and functions of nucleic acids.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
