3′-TBDMS-Bz-rA Phosphoramidite: Overview and Applications
3′-TBDMS-Bz-rA Phosphoramidite, CAS 129451-75-8, is a modified nucleotide used in oligonucleotide synthesis. It features a 3′-TBDMS (tert-butyldimethylsilyl) protective group and a benzoyl (Bz) group on riboadenine (rA).
Key Features:
- 3′-TBDMS Group: Protects the 3′ hydroxyl for selective incorporation.
- Benzoyl Group: Stabilizes the amine at the N1 position of adenine.
- Riboadenine Base: Enhances functionality in RNA sequences.
Applications:
- Oligonucleotide Synthesis: Facilitates RNA sequence synthesis with modified bases.
- Gene Expression Studies: Used in probes and primers to analyze RNA expression.
- Antisense Oligonucleotides: Improves stability for therapeutic use.
- Diagnostics: Aids in developing RNA-based diagnostic assays.
3′-TBDMS-Bz-rA Phosphoramidite is essential for creating modified oligonucleotides in various molecular biology applications.
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