DOTA(OtBu)3
This product is a protected macrocyclic chelator containing three tert-butyl esters. It specifically enables stable radiometal chelation, orthogonal deprotection, and controlled conjugation, offering solubility and synthetic flexibility.
Key Features and Benefits
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DOTA Macrocycle: Provides strong and stable chelation for radiometals such as Ga(III), In(III), and Lu(III).
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t-Butyl Esters: Protect carboxyl groups for staged deprotection and controlled conjugation.
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Synthetic Flexibility: Enables stepwise functionalization and incorporation into complex scaffolds.
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Stability: Protecting groups improve handling during synthesis.
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High Purity: Ensures reproducibility in radiochemistry and drug development workflows.
Applications
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Radiochemistry: Chelates diagnostic and therapeutic radiometals after deprotection.
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Bioconjugation: Serves as a protected chelator for antibody, peptide, or nanoparticle conjugation.
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Probe Development: Builds radiolabeled imaging probes with staged conjugation control.
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Medicinal Chemistry: Supports targeted therapy and diagnostic agent design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture-protected container.
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Handling: Use anhydrous solvents; deprotect under acidic conditions when ready for chelation.
This product specifically integrates strong chelation capability with protective tert-butyl esters, providing stability and flexibility for radiolabeling and conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
