Mal-NH-PEG-NH2.TFA, MW 2K (Maleimide-NH-PEG-Amine.Trifluoroacetic acid) is a maleimide-functionalized polyethylene glycol (PEG) molecule with a molecular weight of 2000 Da, designed for a variety of biomedical applications. This versatile compound combines the properties of maleimide, PEG, and an amine functional group, as well as a trifluoroacetic acid (TFA) counterion.
The maleimide group (Mal) is a reactive functionality known for its ability to form stable covalent bonds with thiol-containing molecules, such as cysteine residues in proteins. The PEG portion is a biocompatible, water-soluble polymer that imparts desirable properties to the conjugated biomolecules.The amine functional group (NH2) at the other end of the PEG chain provides an additional reactive site for bioconjugation. The TFA counterion ensures the molecule’s solubility and stability in aqueous solutions, simplifying its use in various experimental settings.
Mal-NH-PEG-NH2.TFA, MW 2K has been widely employed in medicine, particularly for drug delivery, diagnostics, and targeted therapies. By modifying drugs or targeting ligands with this PEG derivative, researchers can enhance their therapeutic efficacy, minimize side effects, and improve patient outcomes. Examples include PEGylated proteins, antibodies, and nanoparticles designed for targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.