Fmoc-NH-PEG-Mal, MW 2K, is a polymer that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a functional group called Fmoc, which is used to protect the amino group during peptide synthesis, a PEG chain, and a maleimide functional group (-Mal) that enables the conjugation of thiol-containing molecules.
The maleimide group in Fmoc-NH-PEG-Mal is highly reactive with thiol groups, allowing for the formation of stable covalent bonds with thiol-containing molecules such as cysteine residues in proteins and peptides. This property makes it a useful tool in pharmaceutical research and development for the preparation of conjugates that can be used in a variety of applications.
One application of Fmoc-NH-PEG-Mal is in the development of antibody-drug conjugates (ADCs). ADCs are composed of a monoclonal antibody that targets a specific antigen on cancer cells, which is attached to a cytotoxic drug through a linker. Fmoc-NH-PEG-Mal can be used to attach the linker to the antibody via the maleimide group, resulting in a stable and effective ADC that can selectively deliver the cytotoxic drug to cancer cells.
In addition to ADCs, Fmoc-NH-PEG-Mal has also been used in the development of other drug delivery systems, such as liposomes and nanoparticles. The maleimide group can be used to attach therapeutic agents, such as proteins and peptides, to the PEG chain, resulting in improved stability, increased solubility, and prolonged circulation time in vivo.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
