Nutlin-3 is the most commonly used form of nutlin, an inhibitor of p53-Mdm2 interaction and growth of human tumor xenografts in nude mice, by occupying the binding site of p53 in MDM2, thereby preventing MDM2 from binding to p53, thereby preventing MDM2 from binding to p53. Leads to disruption of autoregulatory feedback loops and formation of a p53 tumor suppressor network.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.