Axispharm’s high-purity 3,4-dibromo-Mal-PEG8-acid is a hydrophilic PEG species containing a dibromomaleimide group and a Boc-protected amine group. Dibromomaleimide (DBM) allows two points of attachment because each bromine can be replaced by a thiol to form two thioether bonds. The mild nature and selectivity of the DBM reaction allow the efficient use of sensitive biomolecular reagents. Carboxylic acids are capable of reacting with primary amines in the presence of EDC and HATU to form stable amide bonds. The Boc protecting group can be removed under acidic conditions and allow the amine to react further with other species. Hydrophilic PEG linkers can increase the water solubility of compounds in aqueous media.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
