Methyltetrazine-PEG11-NH-Boc is a versatile bifunctional linker with a methyltetrazine moiety and a Boc-protected amine group, separated by a hydrophilic PEG11 spacer. The methyltetrazine group selectively reacts with strained alkenes and alkynes via bioorthogonal inverse electron-demand Diels-Alder reactions, while the Boc-protected amine enables conjugation to carboxylic acids after deprotection.
In pharmaceutical research and development, Methyltetrazine-PEG11-NH-Boc serves as an invaluable tool for creating targeted drug delivery systems and bioconjugates. Its unique reactivity profile enables site-specific conjugation of therapeutic agents, imaging probes, or other biomolecules to various biological targets.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
